MD Conference Express AHA 2011 - (Page 8)

n F E A T U R E Personalized Cardiovascular Medicine and Drug Development - Time for a New Paradigm Written by Rita Buckley Each year, the American Heart Association (AHA) presents the Lewis A. Conner Memorial Lecture to honor the memory of one of the founders of the AHA. This year, Joseph Loscalzo, MD, PhD, FAHA, Harvard Medical School, Boston, Massachusetts, USA, delivered a presentation on the potential for a more personal, systems- and network-based approach to drug development. Standing at the Crossroads Today, we stand at a crossroads between a one-size-fits-all drug development paradigm and a systems-based approach that incorporates the developing fields of genomics, proteomics, metabolomics, phenomics, pathophenomics, transcriptomics, epigenomics, and metagenomics (Figure 1). Figure 1. Systems Biology and Pathobiology. Genomics Naive Proteomics Modified Metabolomics Metabonomics Phenomics Pathophenomics Transcriptomics, Epigenomics, Metagenomics Functional Genomics/ Proteomics Environmental Perturbations Systems Biology/Pathobiology Reproduced with permission from J. Loscalzo, MD, PhD, FAHA. Peer-Reviewed Highlights from the Integration of systems biology and network analysis is setting the stage for a novel drug development paradigm that is based on the identification of mechanisms that underlie physiological circuits that are corrupted in disease states [Loscalzo J, Barabasi AL. Wiley Interdiscip Rev Syst Biol Med 2011; Waldman SA, Terzic A Clin Transl Sci 2011]. Insights into these processes offer unparalleled opportunities for a network-based approach to human illness [Barabasi AL et al. Nat Rev Genet 2011] and personalized medicine. The goal of personalized medicine is to match precisely the right drug at the right dose to the specific biology of the disease in an individual patient and to maximize therapeutic efficiency while minimizing adverse and off-target effects [Waldman SA, Terzic A. Clin Transl Sci 2011]. The principle itself is straightforward, but its implementation remains challenging [Hamburg MA, Collins FS. N Engl J Med 2010]. scientificsessions.org my.americanheart.org 8 January 2012 www.mdconferencexpress.com  http://www.mdconferencexpress.com http://my.americanheart.org/professional/Sessions/ScientificSessions/Scientific-Sessions_UCM_316900_SubHomePage.jsp http://www.scientificsessions.org http://my.americanheart.org http://www.mdconferencexpress.com

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MD Conference Express AHA 2011

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